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Foxy Methoxy: What is 5-MeO-DiPT? 

foxy methoxy
Written by Alexandra Hicks

Foxy Methoxy is a relatively new synthetic tryptamine that’s becoming increasingly popular for recreational use. Aside from the fact that it’s somewhat easy to manufacture and access, there is not very much to say about Foxy, specifically. But it does open the door to further discussion on tryptamines, how they work, and why so many people are opting for synthetic psychedelics.  

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What is Foxy Methoxy? 

Foxy Methoxy (5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) goes by the chemical formula C17H26N2O, and is also sometimes referred to simply as Foxy. Foxy is a synthetic, psychedelic tryptamine and the methoxy derivative of diisopropyltryptamine (DiPT). Another comparable drug called “Moxy” often gets mixed up with “Foxy”, because of obvious similarities in name, as well as appearance and effects. They are slightly different in chemical structure though (Moxy = 5-MeO-MiPT). 

Foxy comes in tablet, powder, or capsule form and is popular in rave and club scenes where it’s used mainly for its mood enhancing and energizing properties. It’s also said to be great for boosting libido. When it comes to the hallucinations, DiPT is interesting because the effects produced are primarily aural, whereas most psychedelics (both natural and synthetic) come with at least some level of visuals. 

I have never tried it, but this was one Redditor’s experience with Foxy: “I can’t say that it’s like any other [psychedelic]. The come up reminds me of LSD sometimes. It’s not visual most times. Sometimes it is though. Each time was an entirely different experience. It is quite an amazing substance.” Others describe various reactions including: “mild but fun”, “a very crazy body buzz”, “everything felt so surreal”, “incredibly intense mind melding” and “really, really horny”, (that last one came up a lot).  

Overall, a person’s experience will vary based on a myriad of different factors including mood/state of mind at the time of use, personality, set and setting, tolerance, and so much more. Not to mention that, as the above user mentioned, one person can use the same drug on numerous occasions and have a unique experience with different effects every single time. What we can say for sure is that for most users, it changes their mood and lowers inhibitions to some extent – but the level at which that happens is more of a your-mileage-may-vary, kind of thing.  

More on Tryptamines  

On a broader scale, tryptamines (and all derivatives) are indolealkylamine molecules that come from Tryptophan, an essential amino acid found in many plants and animals. In humans, the digestion of dietary proteins in the small intestine leads to the release of tryptophan, which is absorbed by the intestinal epithelium and released into the bloodstream. Once it reaches the brain, the tryptophan undergoes a decarboxylation process and becomes a tryptamine compound, then presenting as a number of different regulating neurotransmitters such as serotonin and melatonin.  

In nature, most tryptamines are psychoactive hallucinogens. Some of the better-known ones include N,N-dimethyltryptamine (DMT), psilocybin and psilocin, and ibogaine. 5-MeO-DMT, or toad DMT, is another popular one. Over the last decade or so, a new generation of synthetic tryptamines have emerged; one of more established one is LSD, but in recent years, drugs like Foxy and Moxy have gaining a bit of notoriety. 5-MeO-DPT, AMT, 4-AcO-DMT and 4-AcODiPT DMT are a few other synthetic tryptamines to make note of.  

Tryptamines act as agonists of the 5-HT2A receptor and are known for creating profound changes in thought processes, temperament, and sensory perception. Tryptamine is a partial agonist of the trace amine-associated receptor hTAAR1. Activation of hTAAR1 is believed to be a potential treatment mechanism for various mood and neuropsychiatric disorders, of particular interest is schizophrenia. Research on other hTAAR1 agonists has found that they produce anti-depressant activity, increase cognition, reduce stress, and minimize addictive behaviors.  

Why Synthetics?  

In the realm of recreational psychedelics, a large portion of users prefer to go all natural with classic entheogens like shrooms and ayahuasca. However, when availability is lacking, people seeking these types of experiences will eventually gravitate to whatever is accessible to them, and in many cases, that just so happens to be something synthetic.  

A few of the main reasons people may choose synthetics over natural compounds include: ease of use and dosing, discretion (think vaping synthetic cannabinoids vs smoking actual weed), and more availability. However, sometimes it’s as simple as preference and how these drugs make a person feel. For example, a lot of people prefer the effects of LSD to psilocybin, despite the former being synthetic. 

Another interesting selling point for synthetics, is that many of them are legal by default. On a global scale, the only tryptamines that are regulated under the 1971 UN convention on psychotropic substances are psilocybin, LSD, DMT, and MDMA. Several others are controlled at the national level in many different countries, but a bunch of the new synthetics manage to fly under the radar for years, even decades, before getting banned.  

For the record, Foxy is illegal in the United States. It became a designated Schedule 1 narcotic on the DEA’s controlled substances list back in 2003, but it’s been known about since back in the mid-1990s. So, Foxy enjoyed quite a few years of slipping through the cracks until federal regulators caught up; and that’s the same song and dance for pretty much every new drug to hit the streets. It’s impossible for lawmakers to create laws against something they have never heard of, and once it reaches the point of needing to be regulated, you can bet there is a large number of people who are already using it.  

Final Thoughts  

Although I wouldn’t describe Foxy as a “popular” drug, it does seem to be making a comeback from its initial appearance in the 90s. I have not had the opportunity to try it, so I can’t draw anything from personal experience on this one, but from what I gathered, the high does seem to be a pleasant and unique experience, like no other. Is it safe? Probably safer than other street drugs, but as a somewhat underground synthetic, not very much information is available. Is it worth trying? Well, that’s up to you to decide. If I’m being completely honest, I prefer natural entheogens in most scenarios, but I’m not 100% against synthetics either and sometimes, the opportunity is ripe to try something new.

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About the author

Alexandra Hicks

Managing editor at Cannadelics and U.S based journalist, helping spread the word about the many benefits of using cannabis and psychedelics.