Summary: A study published in the Journal of Dental Research has found cannabidiol (CBD) to be an effective alternative analgesic for acute dental pain. Conducted by researchers from the University of Texas at San Antonio, the study titled “Cannabidiol as an Alternative Analgesic for Acute Dental Pain” tested the safety and efficacy of CBD, specifically Epidiolex, in relieving emergency dental pain.
Study Validates CBD’s Efficacy in Treating Dental Pain
The clinical trial, which was randomized and placebo-controlled, involved 61 patients aged 18-75 years with moderate to severe tooth pain. Participants were divided into three groups: CBD10, CBD20, or a placebo group. Each group received a dose according to their categorization, and their pain levels were monitored for three hours post-administration.
Pain reduction was measured using a visual analog scale (VAS), along with assessments of pain intensity, maximum pain relief, and changes in bite forces. The results showed that both CBD groups experienced significant VAS pain reduction compared to their baseline and the placebo group. The maximum median VAS pain reduction was 73% from baseline pain at the 180-minute mark. Notably, pain relief in the CBD20 group occurred 15 minutes after administration, compared to 30 minutes for the CBD10 group. Both groups also demonstrated noticeable increases in bite forces, unlike the placebo group.
While side effects such as sedation, diarrhea, and abdominal pain were associated with the CBD groups and not the placebo group, there were no instances of psychotropic effects or mood changes.
The study’s findings are significant, considering the limited options for non-opioid pain relievers. The researchers highlighted the potential of CBD as a dental pain reliever, suggesting it could be an alternative to opioids for acute inflammatory pain conditions. This could help address the opioid epidemic by providing a safer, non-addictive pain management option.
Reference: Chrepa, V.; Villasenor, S.; Mauney, A.; Kotsakis, G.; Macpherson, L. Cannabidiol as an alternative analgesic for acute dental pain. Journal of Dental Research 2023 DOI: 10.1177/00220345231200814.
Source: Cannabis Science
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