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Meet Psilomethoxin, the Love Child of Psilocybin and 5-MeO-DMT 

Written by Alexandra Hicks

A new hallucinogen is emerging that utilizes magic mushroom mycelium to essentially create an orally active form of 5-MeO-DMT: Psilomethoxin

As unbelievable as it may seem, a new hallucinogen is emerging that utilizes magic mushroom mycelium to essentially create an orally active form of 5-MeO-DMT. It’s known as Psilomethoxin, and this novel discovery is not only exciting on the basis of the compound itself, but it also represents a special union of nature, spirit, and science. This could also be a serious game-changer for the future of synthetic psychedelic production.

What is Psilomethoxin? 

Psilomethoxin (4-HO-5-MeO-DMT) is a new tryptamine created in vivo using magic mushroom mycelium. After inoculation, and before the fruiting stage, 5-MeO-DMT is fed into the mushroom substrate, and once the flush comes in, the fruiting bodies contain Psilomethoxin rather than psilocybin or psilocin. It can be made by mixing a pure freebase powder into the substrate, or by using a liquid hydrochloride solution. Psilomethoxin is not a scheduled substance, making it federally legal to possess and consume.

4-HO-5-MeO-DMT is an orally active version of classic 5-MeO-DMT (toad venom) with a longer half live. A drug’s half-life refers to the time it takes for the amount of the active substance in your body to reduce by half. Initial reports indicate that the high from psilomethoxin is very different from both 5-MeO and psilocybin.

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The high is said to be slightly less intense than 5-MeO (in terms of visual and auditory hallucinations), but the trip lasts much longer. Because it seems like a lot of the psilocybin is canceled out during the cultivation process, the longer high could be simply due to the method of consumption, rather than the addition of mushroom compounds. The effects from cannabis edibles lasts longer than those from smoking as well, so it’s not uncommon.  

The Church of Psilomethoxin and the history behind this compound  

Psilomethoxin was initially discovered and synthesized by researchers from the Pasteur Institute, led by Marc Julia, in 1965. The Pasteur Institute, founded in 1887, is a French non-profit center for biomedical research. It was named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. 

The researchers obtained a patent for psilomethoxin, but due to the passing of the Controlled Substances Act in the 1970s, research came to a screeching halt and the patent lapsed after 20 years. The chemists who worked with the compound at the time also claimed that the process of synthesizing it is very elaborate and time-consuming, which can explain why it remained uncommon for so long after its discovery.  


Fast forward a few decades to 2005, and a well-known American chemist, pharmacologist, and author (also the most prolific psychedelic chemist in history) – Alexander Shulgin – took an interest in this long-lost hallucinogen. He theorized that psilomethoxin could be more easily produced by introducing 5-MeO-DMT to magic mushroom substrate, although he never put this theory to practice.  

In 2021, entheogen-based spiritual/religious practitioner Ian Benouis picked up where Shulgin’s idea left off. The experiment was successful and Ian, along with his business and research partners Benjamin Moore and Ryan Begin, performed a week-long dieta to learn more about their new substance. Following a successful journey, the group reached out to attorney Greg Lake and launched the Church of Psilomethoxin, with 4-HO-5-MeO-DMT as their sacrament. The Church of Psilomethoxin is a majority veteran-founded organization and much of its charitable work is directed toward the veteran community, with a focus on mental health.  

According to Church officials, they continued to conduct experiments with psilomethoxin, mainly in the areas of safety and effects. Between November 2021 and September 2022, over 500 entheogen-based spiritual practitioners took part in the research project and gave detailed reports about their experiences. With very few accounts of negative side effects, the church felt confident enough to open their doors to the public in September 2022.

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The future of synthetic psychedelics 

After learning about psilomethoxin, the next logical question is whether or not this process would work with other compounds. How many different substances can be taken up by mushrooms? Imagine growing shrooms with LSD or mescaline… if that was possible, it would be incredible! Others have theorized about adding kratom to substrate and creating 4-HO-mitragagynine, and the list goes on.

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The reality is, it’s likely to only work with other tryptamine compounds. And while lysergamides are a subset of tryptamines, it’s hard to say if uptake would occur with LSD and if it would undergo the same 4-Hydroxylation that occurrs with 5-MeO-DMT. Mescaline would also be a challenge as phenethylamines likely won’t be taken up by mushrooms. 

But back to tryptamines, which are naturally occurring alkaloids found in numerous plants and life forms around the world. There are actually more than 1,500 natural varieties of tryptamine compounds that have been discovered so far. Consider how many orally active tryptamine substances can be created using the mushroom mycelium method. Some have been tested already, such as DET (N, N-diethyltryptamine), which makes 4-HO-DET, but it remains a relatively uncharted sector of the psychedelics industry.

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Final thoughts  

Summarized, psilomethoxin is an edible form of 5-MeO-DMT, and it’s the result of adding 5-MeO to psilocybin mushroom substrate. To clarify, it’s very different than taking 5-MeO and eating some magic mushrooms with it (wouldn’t recommend), as the DMT takes over the mushroom and you don’t really get many effects from the psilocybin. What you do get is a slightly milder, yet longer lasting “God molecule” high. It’s very new, so not much is known about it; but as more information becomes available, we’ll be the first to give you all the updates! 

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1 Comment

  • I love your articles and your work Alexandra, thank you for another insightful and fascinating read!

About the author

Alexandra Hicks

Managing editor at Cannadelics and U.S based journalist, helping spread the word about the many benefits of using cannabis and psychedelics.